منابع مشابه
Adaptive mutation in Escherichia coli.
In 1988 John Cairns, Julie Overbaugh, and Stephan Miller published a paper entitled “The origin of mutants,” in which they suggested that bacteria could choose which mutations to make (11). Shortly thereafter, Cairns and I began collaborating on a National Science Foundation-funded project to investigate the genetic basis of what was popularly called “directed mutation” (although at the time we...
متن کاملRebuttal: adaptive mutation in Escherichia coli (Foster).
If mutations arose in nongrowing cells, as proposed in Foster’s paper (1), then stress-induced mutagenesis would seem inescapable. The plated population certainly grows very little. However, no evidence is provided that reversion occurs in this population and no effort is made to counter evidence to the contrary (see below)—that mutations actually arise in cells growing under selection within d...
متن کاملAdaptive reversion of a frameshift mutation in Escherichia coli.
Mutation rates are generally thought not to be influenced by selective forces. This doctrine rests on the results of certain classical studies of the mutations that make bacteria resistant to phages and antibiotics. We have studied a strain of Escherichia coli which constitutively expresses a lacI-lacZ fusion containing a frameshift mutation that renders it Lac-. Reversion to Lac+ is a rare eve...
متن کاملMutation affecting plasmolysis in Escherichia coli.
A temperature-sensitive mutant of Escherichia coli is described that at the restrictive temperature has lost the ability to plasmolyze. The mutation is located near pyrF.
متن کاملGeneral stress response regulator RpoS in adaptive mutation and amplification in Escherichia coli.
Microbial cells under growth-limiting stress can generate mutations by mechanisms distinct from those in rapidly growing cells. These mechanisms might be specific stress responses that increase mutation rates, potentially altering rates of evolution, or might reflect non-stress-specific processes in rare growing cells. In an Escherichia coli model system, both frameshift reversion mutations and...
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ژورنال
عنوان ژورنال: Journal of Bacteriology
سال: 2004
ISSN: 0021-9193,1098-5530
DOI: 10.1128/jb.186.15.4846-4852.2004